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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP2A1 All Species: 41.21
Human Site: S384 Identified Species: 82.42
UniProt: O95782 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95782 NP_570603.2 977 107546 S384 L K T E R D V S V R Q R A A D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001115458 977 107553 S384 L K T E R D V S V R Q R A A D
Dog Lupus familis XP_541490 922 101289 I365 D Y A I R E E I V L K V A I L
Cat Felis silvestris
Mouse Mus musculus P17426 977 107646 S384 L K T E R D V S V R Q R A A D
Rat Rattus norvegicus P18484 938 104026 S383 L K T E R D V S V R Q R A V D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001012914 938 104174 S383 L K T E R D V S V R Q R A V D
Frog Xenopus laevis NP_001089303 939 104392 S384 L K T E R D V S V R Q R A V D
Zebra Danio Brachydanio rerio XP_001922441 959 106027 S384 L K T E R D V S V R Q R A A D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91926 940 105602 S384 M K M E K D V S V R Q M A V D
Honey Bee Apis mellifera XP_394621 937 104937 S384 M K M E K D V S V R Q Q A V D
Nematode Worm Caenorhab. elegans NP_509572 925 104161 S383 L K T E R D V S V R Q R A V D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38065 1025 114993 S440 L N T E R D S S I V R K V V D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.5 91.3 N.A. 98.4 79.4 N.A. N.A. 79.5 78.3 82.1 N.A. 66.6 68 62.2 N.A.
Protein Similarity: 100 N.A. 99.8 92.7 N.A. 98.8 86.9 N.A. N.A. 87.4 87 88.1 N.A. 77.8 78.8 74.9 N.A.
P-Site Identity: 100 N.A. 100 20 N.A. 100 93.3 N.A. N.A. 93.3 93.3 100 N.A. 66.6 66.6 93.3 N.A.
P-Site Similarity: 100 N.A. 100 33.3 N.A. 100 93.3 N.A. N.A. 93.3 93.3 100 N.A. 80 86.6 93.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 0 0 0 0 0 0 0 0 92 34 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 0 92 0 0 0 0 0 0 0 0 92 % D
% Glu: 0 0 0 92 0 9 9 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 9 0 0 0 9 9 0 0 0 0 9 0 % I
% Lys: 0 84 0 0 17 0 0 0 0 0 9 9 0 0 0 % K
% Leu: 75 0 0 0 0 0 0 0 0 9 0 0 0 0 9 % L
% Met: 17 0 17 0 0 0 0 0 0 0 0 9 0 0 0 % M
% Asn: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 84 9 0 0 0 % Q
% Arg: 0 0 0 0 84 0 0 0 0 84 9 67 0 0 0 % R
% Ser: 0 0 0 0 0 0 9 92 0 0 0 0 0 0 0 % S
% Thr: 0 0 75 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 84 0 92 9 0 9 9 59 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _